The DIAN and NACC UDS Comparison Study

 
   Lead Investigator:    Virginia Buckles
   Institution      :    Washington University School of Medicine
   E-Mail           :    bucklesv@abraxas.wustl.edu
   Proposal ID      :    541


   Publications:


1  Buckles V, Xiong C, Weng HB, Bateman R, Chhatwal JP, Ghetti B, Goate A, Graff-Radford NR, Hassenstab J, Mayeux R, Masters C, McDade E, Moulder KL, Paumier K, Ringman JM, Salloway S, Schofield PW, Morris JC, the Dominantly Inherited Alzheimer Network
   The Dian-NACC UDS Comparison Study: Rates of Cognitive Decline
   Abstract  Alzheimers Dement,12:P309,2016,

   PUBLISHED



2  Buckles VD, Xiong C, Bateman RJ, Allegri R, Benzinger TLS, Berman S, Cairns NJ, Chhatwal J, A D, Fagan AM, Ghetti B, Goate A, Graff-Radford N, Jassenstab J, Jucker M, Levin J, Marcus D, Martins R, Masters C, Mayeux R, McCue L, McDade E, Mori H, Moulder K, Paumier K, Ringman J, Rossor M, Salloway S, Schofield P, Morris JC
   Rates of Cognitive Decline in Dominantly Inherited Versus Sporadic Alzheimer Disease
   2018   Journal Article  Neurology , 

   REVISION





   Proposal Description:
   The principal research question will address similarities and differences between late-onset sporadic AD (LOAD) and early-onset autosomal dominant AD (ADAD) in clinical and cognitive course.  Storandt, Balota, Aschenbrenner and Morris (2014) examined the cross-sectional clinical and psychological characteristics of DIAN mutation carriers compared with non-carriers, all from kindreds afflicted with causative mutations.  When comparing mutation carriers to non-carriers, both asymptomatic, they found that non-carriers performed better than mutation carriers on Logical Memory delayed recall and Semantic Categorization accuracy.  When expected age at onset was used for regression, asymptomatic mutation carriers had steeper downward slopes in Digit Symbol and Logical Memory, both Immediate and Delayed, than asymptomatic non-carriers.    Specific Aims:  1. Prepare appropriate analytic datasets from DIAN and NACC participants.  2. Compare asymptomatic LOAD and ADAD participants on psychometric (UDS) measures (replication of Storandt et al. 2104) both cross-sectionally and longitudinally.  3. Compare asymptomatic LOAD and ADAD participants on clinical (UDS) measures (FAQ, GDS, NPI-Q, etc.) both cross-sectionally and longitudinally.